1,2-diphenyl-2-[(tetrahydro-2H-pyran-2-yl)oxy]ethan-1-one

  • Name: 1,2-diphenyl-2-[(tetrahydro-2H-pyran-2-yl)oxy]ethan-1-one
  • CAS: 51706-34-4
  • Purity: 99%
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Details

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  • Molecular Formula: C19H20 O3
  • Molecular Weight: 296.366
  • Vapor Pressure: 4.01E-08mmHg at 25°C 
  • Boiling Point: 445.2°C at 760 mmHg 
  • Flash Point: 215°C 
  • PSA: 35.53000 
  • Density: 1.15g/cm3 
  • LogP: 4.15380 

1,2-diphenyl-2-[(tetrahydro-2H-pyran-2-yl)oxy]ethan-1-one(Cas 51706-34-4) Usage

Chemical structure

A derivative of curcumin, a natural compound found in turmeric.

Antioxidant properties

Acts as a powerful antioxidant, neutralizing free radicals and reducing oxidative stress in the body.

Anti-inflammatory properties

Exhibits anti-inflammatory effects, potentially reducing inflammation in the body.

Potential health benefits

Has been studied for its potential to protect against neurodegenerative diseases and may have anti-cancer effects.

Skin-lightening properties

May be used in skincare products for its ability to brighten and even out skin tone.

Therapeutic potential

Shows promise as a therapeutic ingredient due to its antioxidant, anti-inflammatory, and potential health benefits.

Cosmetic potential

May be used in the cosmetic industry for its skin-lightening and skin-brightening properties.

Safety

Generally considered safe for use in skincare products, but further research is needed to determine optimal dosages and potential side effects.

Stability

May have improved stability compared to curcumin, as it is less prone to degradation and has better bioavailability.

Research status

While tetrahydrocurcumin has shown promising results in preliminary studies, more research is needed to fully understand its potential benefits and applications.

General Description

1,2-diphenyl-2-[(tetrahydro-2H-pyran-2-yl)oxy]ethan-1-one, also known as tetrahydrocurcumin, is a derivative of curcumin, which is a natural compound found in turmeric. Tetrahydrocurcumin is a powerful antioxidant and anti-inflammatory compound that has been studied for its potential health benefits, including its ability to reduce inflammation and oxidative stress in the body. It has also been shown to have potential anti-cancer effects and may help protect against neurodegenerative diseases. Additionally, tetrahydrocurcumin has been studied for its potential skin-lightening properties and may be used in skincare products for its ability to brighten and even out the skin tone. Overall, 1,2-diphenyl-2-[(tetrahydro-2H-pyran-2-yl)oxy]ethan-1-one shows promising potential as a therapeutic and cosmetic ingredient.

InChI:InChI=1/C19H20O3/c20-18(15-9-3-1-4-10-15)19(16-11-5-2-6-12-16)22-17-13-7-8-14-21-17/h1-6,9-12,17,19H,7-8,13-14H2

51706-34-4 Relevant articles

Anhydrous FePO4 as a cost-effective and recyclable catalyst for tetrahydropyranylation and tetrahydrofuranylation of alcohols and phenols

Behbahani, Farahnaz K.,Farahani, Mona

experimental part, p. 431 - 435 (2012/04/17)

In this article, a mild and efficient pr...

Generally applicable organocatalytic tetrahydropyranylation of hydroxy functionalities with very low catalyst loading

Kotke, Mike,Schreiner, Peter R.

, p. 779 - 790 (2008/01/03)

This paper presents the first acid-free,...

Silylation and tetrahydropyranylation of alcohols catalyzed by Al(HSO 4)3

Shirini, Farhad,Zolfigol, Mohammad Ali,Abedini, Masoumeh

, p. 1982 - 1985 (2007/10/03)

Trimethylsilylation and tetrahydropyrany...

Potassium dodecatangestocobaltate trihydrate (K5CoW12O40·3H2O): A mild and efficient catalyst for the tetrahydropyranylation of alcohols and their detetrahydropyranylation

Habibi, Mohammad H.,Tangestaninejad, Shahram,Mohammadpoor-Baltork, Iraj,Mirkhani, Valiollah,Yadollahi, Bahram

, p. 2851 - 2853 (2007/10/03)

A simple, mild and effective method for ...

51706-34-4 Process route

3,4-dihydro-2<i>H</i>-pyran
110-87-2

3,4-dihydro-2H -pyran

2-hydroxy-2-phenylacetophenone
119-53-9,579-44-2

2-hydroxy-2-phenylacetophenone

benzoin tetrahydropyranyl ether
51706-34-4

benzoin tetrahydropyranyl ether

Conditions
Conditions Yield
With aluminum(III) hydrogen sulfate; In hexane; at 20 ℃; for 4h;
65%
With N.N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea; at 50 ℃; for 26h;
59%
K5 ; In acetone; at 20 ℃; for 0.166667h;
80 % Chromat.
With iron(III) phosphate; In dichloromethane; at 20 ℃; for 7h;
86 %Chromat.
tris(ethylenedioxyboryl)methane
59278-44-3

tris(ethylenedioxyboryl)methane

benzoin tetrahydropyranyl ether
51706-34-4

benzoin tetrahydropyranyl ether

(Z)-2,3-diphenylacrylaldehyde
72659-45-1,1755-47-1

(Z)-2,3-diphenylacrylaldehyde

phenylacetaldehyde
122-78-1

phenylacetaldehyde

benzaldehyde
100-52-7

benzaldehyde

Conditions
Conditions Yield
Multistep reaction. Yields of byproduct given;
Yield given. Multistep reaction;

51706-34-4 Upstream products

  • 110-87-2
    110-87-2

    3,4-dihydro-2H -pyran

  • 119-53-9
    119-53-9

    2-hydroxy-2-phenylacetophenone

51706-34-4 Downstream products

  • 72659-45-1
    72659-45-1

    (Z)-2,3-diphenylacrylaldehyde

  • 122-78-1
    122-78-1

    phenylacetaldehyde

  • 100-52-7
    100-52-7

    benzaldehyde

  • 119-53-9
    119-53-9

    2-hydroxy-2-phenylacetophenone

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